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MPO mediates the vascular inflammation that propagates plaque development and activates protease cascades which have been linked to plaque vulnerability. White blood cell activation inside the bloodstream, in response to luminal injuries from the artery wall including fissures, erosions or even a degrading collagen cap, brings about MPO launch in the bloodstream.

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Notice: Continual inflammatory health conditions may exhibit elevated MPO values as a consequence of increased vascular sickness associated with these disorders. For instance, RA is associated with a 5x elevated danger for myocardial infarction.

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